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Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospitals

Release time: Sept 29,2022 Reading volume: 156 Source: wfcms
Abstract:
Objective:To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in China.Methods:A prospective,multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3,2016 to February 17,2019.A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk factors.Additionally,stroke recurrence was defined as a primary outcome indicator.Results:A total of 327(12.78 %) patients endured recurrence events,1,681(65.72%) patients were men,and the average age was 63.33±9.45 years.Totally 1,741(68.06%) patients suffered first-ever ischemic stroke,1,772(69.27%) patients reported to have hypertension,and1,640(64.11%) of them reported dyslipidemia,1,595(62.35%) patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment(TOAST) classification.Specifically,1,271(49.69%) patients were considered as qi-deficient constitution,and 1,227(47.97%) patients were determined as stagnant blood constitution.There were 1,303(50.94%) patients diagnosed as blood stasis syndrome,1,280(50.04%) patients exhibited phlegm and dampness syndrome and 1,012(39.56%) patients demonstrated qi deficiency syndrome.And 1,033(40.38%)patients declared intracranial artery stenosis,and 478(18.69%) patients reported carotid artery stenosis.The plaque in 1,508(41.36%) patients were of mixed.Particularly,41.09% of them demonstrated abnormal levels of glycated hemoglobin(HbA1 c) levels.Conclusions:Recurrence in minor and small-artery stroke cannot be ignored.Hypertension,dyslipidemia,abnormal HbA1 c,intracranial artery stenosis and carotid plaque were more common in stroke patients.Particularly,phlegm-dampness and blood stasis syndromes,as well as qi deficiency and blood stasis constitutions,were still the main manifestations of stroke.(Trial registration at ClinicalTrials.gov,No.NCT03174535)

Keywords:
noncardiogenic ischemic stroke;Chinese medicine hospital;onset characteristics;recurrence

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